I did this for a few years with one SSD in various laptops or desktops as logisitics warranted. Desktop at home, 12in Thinkpad while traveling, 14in Thinkpad at work. It was easy to swap drives with the Thinkpad drive bay that they used to have.

Sadly, once most laptops went over to NVME 2280 pcie cards, it got a little too tedious to constantly swap out drives any more, and I started worrying about accidentally breaking them. Also had some weird issues with very poor write speed which I thought was overheating necessating a heat sink, but it turns out nvme speeds are actually just as slow as anything else under real workloads.