If someone told you a cup may contain poison, would your first reaction be to drink it just to be sure?
https://arstechnica.com/tech-policy/2014/05/photos-of-an-nsa...
Your example of highly-targeted physical interception by state-level actors is irrelevant here.
Essentially, this means that there is zero risk, unless you are a target, at which point any unintentional hardware bug caused by the aforementioned corner-cutting will become a concern.
[0] https://linux-sunxi.org/Linux_mainlining_effort
btw, I asked about this 5 months ago [0] and got some interesting replies. I ended up purchasing a PCEngines board (just before they went out of business)