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Comment by fasteo | Hacker News Reader

For what it's worth mildronate (meldonium), the drug taken by several elite athletes (pe. Maria Sharapova), is a potent fatty acid inhibitor.

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What does "pe." mean in this context?

per example

i.e. = id est = definition of

e.g. = exempli gratias = for example

PE = pulmonary embolism, performance enhancing

Physical Exercise

Polyethilene

PED: Performance Enhancing Drug

price/earnings

Possibly the abbreviation of a romance language (French, Spanish, Italian, Portguese etc.) spelling of "for example" ("par exemple", "por ejemplo", "per esempio", "por exemplo"...)

OP here: You've got it. Spaniard, "por ejemplo"

That makes way more sense than english's weird use of the latin e.g. for exempli gratia. And now I learn the actual romance languages don't even use it.

(fatty acid oxidation inhibitor)

How are their hearts?

Judging from the uptick in athlete deaths the last few years, I wouldn't say players are doing too well with whatever they're doing.

Here is a Wikipedia page with soccer players that died on the field. 2021 was a rough year which makes you think either a few deaths from what would have happened in 2020 ended up moving into 2021, or covid was really bad for everyone, even athletes.

https://en.m.wikipedia.org/wiki/List_of_association_football...

Not unreasonable that this mechanism normally disables to prevent problems though.

The point of research like this would be to restore normal function after heart injury.

The vaccine had a detrimental effect on the heart health of especially young males: https://www.bmj.com/company/newsroom/new-study-updates-evide...

The 2021 deaths began in January, before the vaccine was widely rolled out to young people.

Not to minimize vaccine myocarditis, but it is myopic to focus on that and not the extremely contagious disease known to cause heart trouble.

>The 2021 deaths began in January

Interesting claim, can you back that up with data?

The list you posted has data supporting this.

14 died in 2016 - I guess from vaccine right?

The virus itself had a strong detrimental effect on the heart health of especially young males.

Even if you take as given that the vaccine had harmful effects, it's dishonest to single it out without comparison to the impact of getting full fledged COVID.

What uptick? Doesn't look any worse than 2010 or 2013. It's likely within a standard deviation for the last decade or two.

2021 was a particularly bad year (after a 'miracle' year in 2020), but the 3 year rolling average of 2018-2021, 2019-2022, or 2020-2023 is probably within an SD of any other rolling average since these types of stories got widely reported by the internet rather than being a local tragedy.

A long-term break from extended stress and athleticism, followed by a return to extreme athleticism, which resulted in a single particularly bad year (2021 - 20 deaths)?

Notably there are fewer deaths in 2022 (8) than 2019 (10) 2018 (9), and 2017 (10). 2023 looks to be in keeping with that trend. It looks far more like 2021 was a single outlier year with reasonable explanations than an 'uptick', which implies an ongoing trend, which the data you're showing simply doesn't show.

Another factor could be that those who had congenital heart conditions who would have died in normal play in 2020 (2) are among those who died in 2021.

Data shows no such uptick across sports. I think your mistaking a reporting bias or your own bias towards such stories as data.

As someone who has seen elite athletes in hospitals: really solid, their heart rate is so low it'd be bradycardic in a normal person.

I remember being like that, even wondered if something was wrong with me - no longer - I stopped training like I used to and now my heart rate is average / high.

You are only seeing them before they are sick...it is well know that too much exertion is as bad as too little.

https://blogs.bmj.com/bjsm/2017/04/06/elite-athletes-higher-...

It doesn't seem like your link supports your assertion. It says:

"In fact, there is a large body of research supporting that the population that perform the highest levels of physical activity (i.e. elite athletes) seem to present a lower risk of CV diseases and mortality. Specifically, a meta-analysis including 42087 elite athletes reported a 27% lower risk of mortality associated to CV diseases in comparison with the general population (Garatachea et al., 2014). Furthermore, an epidemiological study that analyzed 15174 Olympic medalists found that these subjects lived a mean of 2.8 years more than the average population, independently of the country or the type of sport performed (Clarke et al., 2012)."

Did you bother to read that before you posted it? Because it does not support your claim, at all.

Atheletes live longer (https://bjsm.bmj.com/content/55/4/206) and more importantly live morbidity free lives much longer.

Make no mistake, Meldodium is a therapeutic option[1] for cardiac disease in many eastern countries (Latvia, Russia,Ukraine, Georgia, Kazakhstan, Azerbaijan, Belarus,Uzbekistan, Moldova and Kyrgyzstan).

[1] Some brand names include: Cardionate, Idrinol, Medatern, Melfor, Midolat, Mildroxyn, Metamax, Metonat, Trizipin, Vazonat, Vazopro, etc

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