The NUC's GPIO header: crickets
There was also the UP Board which was an Atom SOC with PI compatible GPIO. I believe that's still in production?!
https://up-shop.org/up-board-series.html
Then again that is severely dated, the Atom was a very capable processor... when it launched, almost a decade ago.
If you want a small PC for media/homelab server/cheap desktop, they don't make any real sense anymore.
There are other cheaper boards for USB to GPIO out here as well.
Eventually those boards run into limitations and then you have to just opt to go with serial to a microcontroller which misses the entire point of having a SBC.