My wife is a psychiatrist. She told me I the past that anti-depressants are a bit like roulette - you have to keep trying until the right one lands. Unfortunately, that can take years as most antidepressants take 4 to 8 weeks to take full effect. Everybody’s body is just slightly differently so it can take a while to find a drug that pairs well with your body.

Further, there’s a lot of indication that antidepressants depressants are far, far more effective when paired with cognitive behavioral therapy (CBT). I think of this like liposuction, you can remove the weight quickly - but without sustained lifestyle and diet changes, you’ll end up being back in the same place.