```
# Please don't change this. We don't support it, because the
# default shell profile that comes with Nix doesn't support it.
readonly NIX_ROOT="/nix"
```
I haven't seen any configurations where the entire /nix is relocated, but nix _does_ support relocating the store with the environment variable `NIX_STORE_DIR`.[1]
However, this means that you can no longer use the the binary cache and *everything* you install has to be compiled from scratch, including glibc. The reason is that nix usually patches paths like `/bin/myprogram` to `/nix/store/1238f...-myprogram-1.2.3/bin/myprogram` in everything that depends on `myprogram` during build time to isolate the build outputs from the system. If you change your store, all those paths will now be invalid, including the hash part.
So using a nix store that isn't `/nix/store` is possible, but I don't think anyone is actually doing it except in a few select scenarios.
You can also compile nix itself with a different root. That will work as expected, but you still have the issue that you need to compile everything you install yourself.
[1]: https://nixos.org/manual/nix/stable/command-ref/env-common.h... (you can also relocate most other directories. The `prefix` in the paths is `/nix`)