I was talking to a grad student who was having an issue getting descent flat frames (images of a uniform field, used to account for dust and optical train effects). I asked why she didn't just take a picture of the sky in the daytime like most amateurs do, and she said she always ends up with stars in the image doing it that way. They tried finding the least populated part of the sky, but still always picked up stars.
This link explains them in more detail:
https://www.highpointscientific.com/astronomy-hub/post/astro...
Instead, you want one of these!
https://support.phaseone.com/knowledgebase/article/KA-01239/...
I guess you'll need something like an integrating sphere? https://en.wikipedia.org/wiki/Integrating_sphere
Photography reviews often measure vignetting by putting a piece of tissue paper on the lens lol.
Some people do use tissue paper, or a t-shirt over the lens, and that works for making pretty pictures. But she said none of them come close to 1% accuracy.
But now you have me wondering how the big telescopes do it. Things like the JWST or HST, or even large ground based scopes don't really have any of those options.