There are some ways to mitigate this, although they're not always possible depending on the setting:

* Get a good sleep, ideally at about the same time as usual. If you normally sleep 11pm-7am then obviously a 4am-8am sleep is obviously going to have an effect on your mood. The closer you can get to your normal routine, the better. This might mean taking it pretty early, which doesn't necessarily make sense in a club setting.

* Take magnesium before/during the high to prevent gurning (if this is a problem). A sore jaw makes everything worse the next day.

* Take 5-HTP as soon as you wake up.

* Either sleep in the same house as the people you dropped with, or get back together as soon as possible in the morning. This is essential to processing the experience in a positive, social way.

* Don't have anything scheduled involving work or family for at least a couple of days afterwards, ideally a week.

It's not really the next morning, there was usually a "glow" that lasted for a couple of days. It was mostly midweek that the depression sunk in, and really that only happened to me after I had been going to raves regularly for a year.

Mostly for me it was a matter of understanding what the cause of that was. But yes, over time it was what stopped from me from continuing to take it, but all the benefit I really got out of it, therapeutically, happened in the first 2 or 3 times I took it, before I ever had the mid-week crash. Everything after that was just for fun.

How much sleep are you getting afterwards? If it's laced with any type of amphetamine, probably not very much, and from my personal experience, the sleep dep feels like the main problem and not the after-effects of the substance itself.

I read about NAC (N-Acetyl L-Cysteine) in various forums and it seems to be a relatively safe antioxidant that does wonders for MDMA after effects and "losing the magic". YMMV but I highly recommend.