Rp2040 is a decent choice for relatively slow speed digital bus multi-tool, but the USB1.1 speeds will be somewhat limiting (IIRC I achieved somewhere around 700-800KB/s of serial data throughput). PIO is also flexible enough for some almost standard-but-nonstandard digital buses (for example, I used it to interface with 12-bit SPI-like interface- not many MCUs support word-widths that are not multiple of 8 for their hardware SPI interfaces).