Litestream adds reliability to a system using SQLite by periodically backing-up the SQLite database to something like AWS S3. If you lose the node running your SQLite database, you must restore it from your backup.

rqlite, in contrast, adds reliability and high-availability via clustering. This means that any application talking to rqlite shouldn’t notice if a node fails because other nodes in the cluster automatically take over. But rqlite is not a drop-in replacement for SQLite.

https://rqlite.io/docs/faq/#how-is-it-different-than-litestr...