HUBSPOT has over 700, my guess is close to 800 and they charge like $200 per month (~$140-160k per month)

LEADS360 was doing like $400k in rev per month in late 2007.

37SIGNALS obviously, is doing well, I'm guesstimating $10 mill, at least.

ZOHO is doing like $40 million a year.

CONSTANTCONTACT is doing $50+mill a year.

Then of course, there is SALESFORCE.