I do think after watching how unpredictable the weather is getting, that greenhouses and indoor growing will be a very important part of the puzzle in the mid to later parts of this century. I worry about the grain crops and things that are still very much an outdoor proposition. Genetic modification and experiments with different perennials may get us to a place of resiliency, but we're not there yet.
FWIW, I'm not anti-GMO. But I think an issue with GMOs is that a lot of what it gets used for is making crops tolerant of tons of chemical spraying.
If we get a lot of cheap energy it might make sense if it would allow to basically free up the land for farming.
But as long as land is not "expensive", it's just too expensive in comparison.
Sun is free and land is cheap, tons of plastic, bulbs and infrastructure is not.