I only tested NATS using JetStream and I struggled with the throughput in Python. I probably used it wrong. But your comment may imply that jetstream is slow.
As an example, the C# API was originally very 'go-like' and written to .NET Framework, didn't take advantage of a lot of newer features... to the point a 3rd party client was able to get somewhere between 3-4x the throughput. This is now finally being rectified with a new C# client, however it wouldn't surprise me if other languages have similar pains.
I haven't tested JetStream but my general understanding is that you do have to be mindful of the different options for publishing; especially in the case of JetStream, a synchronous publish call can be relatively time consuming; it's better to async publish and (ab)use the future for flow control as needed.
Those numbers are for server 2.9.6 and .NET client 1.0.8.