I'd love to be using Cloudflare as our cloud provider, but it didn't seem to make a lot of sense for our use case.
We were concerned with some of the performance benchmarks we've seen with R2 in the past (though they've probably have improved), not to mention our compute options become a bit more limited to bandwidth alliance clouds otherwise we'll be eating network egress fees (which I do hate with a HUGE passion).
Though I can imagine if you're comfortable with one of the bandwidth alliance clouds already and can take a bit of a perf hit for search, R2 and Backblaze both can provide some cost savings depending on your workload.