Ozempic Can Cause Major Loss of Muscle Mass and Reduce Bone Density
healthline.com
healthline.com
“Any time people lose weight, one-quarter to one-third of that weight can be muscle, and the faster we lose, the more likely we are to lose muscle. While 20% reduction in muscle mass seems normal for someone losing weight, the problem is the length of time in which this muscle loss occurs,” said Kumar.
To your point, we know lifting weights specifically is crucial for maintaining bone mineral density[1]. I wonder if there’s a correlation between loss of lean mass and reduced bone mineral density.
[1] Crucial being a relative term with respect to the applicability of this study’s findings https://pubmed.ncbi.nlm.nih.gov/31797417/
Edit: for sourcing.
On the other hand the evidence on running and bone density is very consistent.
https://www.nm.org/healthbeat/healthy-tips/fitness/is-runnin...
By hunkering down on the couch and just losing weight you get the winter scenario. By exercising while you lose weight you get the summer scenario.
I also use a scale that does body mass measurements (consumer grade). It says:
1. My fat-free body weight went from 148.6 down to 143.2.
2. My muscle mass is down from 142 down to 136 (see below)
3. I have had no bone loss of bone mass.
As I was walking, I seemed to consistently lose about 25% of the weight in muscle. My weight loss stopped as I started hitting the weights, but I started putting on about a pound per month in muscle, which is very visible on my core and arms.
Peter Attia has a nuanced medical take on the drug, based on interactions with his patients (short video https://www.youtube.com/watch?v=T6fhFLv2ERs). His take was that the drug works and there are very few side effects. He also uses it as a last resort, as he has seen his patients lose far more bone mass and muscle than he would like. However, it is a lifesaver for people who don't have success with other methods.
Personally, I don't want to use it, but don't judge others for making the right medical decisions for themselves.
This looks a bit like a supplement ad.
It would not surprise me at all if the makers of things like Ensure are scared of weight loss drugs and are trying to find a way to stay relevant.
I see this more as an opportunity? "Hey, this new drug is all great, but focus your reduced caloric intake on the proper macros, brozempic!"
If so, I'm honestly not surprised at all. Magic bullets don't exist. If they do, they usually come with unforeseen side effects.
It's only a side-effect if it's secondary or undesirable.
[edit] Or (setting aside the birth defects) curing multiple myeloma was a side-effect of thalidomide, which was originally given for morning sickness. And life extension is a promising potential side-effect of metformin.
What is your point? that's the definition... A side effect of turning the light on is heat.
"A peripheral or secondary effect, especially an undesirable secondary effect of a drug or therapy."
But since so many are using it JUST for weight-loss, which their insurance probably doesn't cover, I sometimes have to wait because it's sold out. So me, having a legit reason to be on it due to my diabetes, can't always get it because someone else wants it just to lose weight.
You mean they "just" want to reduce their blood pressure, reduce their cholesterol, reduce their glucose, reduce their chances of cancer, stroke, coronary heart disease, all the while moving easier, having more energy, and not feel embarrassed by their weight any longer.
(There is high correlation between overweight to obese to be pre-diabetic or undiagnosed/untreated diabetic)
The longterm success number for those that lose significant weight and keep it off for many years, are abysmal.
Moreover these drugs are not going to get people an "optimal beach body"; they might at best help to get weight in the range where work can start on that.
In fact for people at normal weight looking to improve their appearance these drugs would probably be counterproductive, for the reasons mentioned in the study. When the goal is to optimize for aesthetics a low body fat percentage is key. That requires a solid amount of muscle mass, and a drug regimen that catabolizes muscle is going to be counterproductive.
https://www.healthline.com/health/obesity-facts#statistics
It's probable that the demand is overwhelmingly coming from that large cohort. Which wouldn't be "cosmetic" weight loss.
Then you have to pay for the drug out of pocket, that's a 5 figure sum annually. You can get a nutritionist, personal trainer, and meal prep for less in a lot of the country. Oh yeah and it also requires injections, a lot of people hate needles.
As another poster pointed out, 2/3 of the country are overweight or obese. There's plenty of medically qualified patients around, no need to assume some epidemic of already-thin people taking Ozempic to try to get six-pack abs.
You are wildly underestimating how many doctors are willing to prescribe medicines without a strong need. Have you heard of the opiod epidemic?
> Then you have to pay for the drug out of pocket, that's a 5 figure sum annually.
Unless you can convince your insurance company to pay for it -- say, with the help of a willing doctor. And even if you can't, there are a surprising number of people who will pay that kind of money for weight loss.
> You can get a nutritionist, personal trainer, and meal prep for less in a lot of the country.
You've been able to get those things for many years. They are not the same as an easy weight loss drug.
> As another poster pointed out, 2/3 of the country are overweight or obese.
The medical definition of "overweight" is quite broad, and clinically it's based on BMI, an extremely flawed measurement at an individual level. There are certainly plenty of people with a medical need for a weight loss drug! (I am one of them!) But there are also plenty of people who think they are ugly because they are 10-15 pounds over their "ideal" weight and have one little roll of belly fat. There is a strong tendency to medicalize this kind of problem. This is a pretty big part of American culture. Have you not encountered this before?
What I'm arguing here is that when a drug is in limited supply the people with an immediate need for it (diabetics) ought to take precedence over people who are worried about potential future health problems somewhere down the line (younger, mildly obese people), and that people who are mainly worried about cosmetics ought to wait for wider availability. I don't think that's controversial?
Opioids don't cost $10k+ a year out of pocket.
> Unless you can convince your insurance company to pay for it -- say, with the help of a willing doctor.
Even with "good insurance", it's quite difficult to get Ozempic covered for weight loss, even if you are obese - let alone normal weight or just overweight. Not speculating here, I know people who meet the criteria and have tried.
> You've been able to get those things for many years. They are not the same as an easy weight loss drug
Yes, and that's one of the many reasons why obesity rates are lower among the wealthy. I don't think that paying over $1k a month and getting weekly injections is especially "easy."
> What I'm arguing here is that when a drug is in limited supply the people with an immediate need for it (diabetics) ought to take precedence over people who are worried about potential future health problems somewhere down the line (younger, mildly obese people), and that people who are mainly worried about cosmetics ought to wait for wider availability. I don't think that's controversial?
What evidence do you have that this is not occurring? I see a lot of evidence that insurance companies are aggressively rationing Ozempic for non-diabetic patients - both in the news media and in my personal life. Many of those paying out of pocket for semaglutide are getting it from compounding pharmacies because they can't get access to the brand name drug, either due to cost or supply constraints.
eat less and move more.
There was a 16% weight loss for those that received semaglutide/diet/exercise/counseling versus a loss of 5% for placebo those that received diet/exercise/counseling without semaglutide.
/s
Ozempic basically decreases appetite. That's its main weight loss mode of action.
Stomach stapling basically decreases appetite.
Ozempic acts with more precision by targeting your insulin release/sensitivity and addiction centers of the brain -- and making sugars/carbs harder to process.
There seems to be some reports of folks suffering from rare stomach paralysis.
That, however, might not be as attention-getting/click-baity a title.
Eating all that garbage still had a negative effect on your health while if you want to loose that weight with this medication you need to change what you eat more than how much.