Rapacmycin, acarbose, glycine, canagliflozin and 17-a-estradiol [1]. Acarbose’s side effects include “flatulence (78% of patients) and diarrhea (14% of patients)” [2]. (It also appears to be hard on the liver.)
[1] https://www.nia.nih.gov/research/dab/interventions-testing-p...
i.e. semaglutide for weight loss, canagliflozin for longevity, etc.
Diabetes drugs improve or replace the role of insulin, through differing mechanisms, so it makes sense that they would have some of the same benefits.
It’s fairly safe to discount any study that indicates significant health effects from a nonessential amino acid, especially in animal models.
One, that’s too much confidence for a topic we do not understand well. Two, the study found—with startlingly high confidence and a meaningful, if small, effect size—glycine “can mitigate methionine toxicity,” the latter being an essential amino acid [1].