Would be nice if it was 64bit. Seems a bit late.
The biggest difference for me is the difference in the calling convention. In 32 bit, all arguments generally are placed on the stack for "standard" calls. In 64 bit, different OSes have different conventions:
http://en.wikipedia.org/wiki/X86_calling_conventions#x86-64_... (note that OS X and linux use the "System V" calling conventions)
On Windows, amd64 is much better than x86 in this regard because of the bevy of x86 calling conventions that are still around. Only one amd64 calling convention.