AWS does not have a 100% similar VM, but you could have something close for ~ 20,000 USD monthly. Not that bad.
However, storage costs alone would be astronomic. Like > 100,000 USD / month.
I have no idea how much outbound traffic Let's Encrypt serves, but that also could be a quite relevant expense.
OFC I also don't know how much Let's Encrypt pays for energy, cooling, operations, real estate, etc... but:
> I bet that compared to an equivalent load hosted on AWS, that lovely box pays for itself in full every month
I would not take the other side on that bet