Some people experience various, mostly mild, forms of cognitive impairment such as sleepiness, thinking everything is funny, and memory issues. Other people seem to enter a state of heightened idea generation, like more of their brain is working on ideation than usual, and perhaps the sort of thing a priest class would find useful (thinking back to when this plant would have been domesticated). I’m sure there are many other types of reaction as well.
If someone experiences priest mode or is around those that do, they will be more positive towards it than others who only see impairment mode. It is much less homogenous in its effect on people than alcohol is.