Vaccine Reverse Multiple Sclerosis, Type 1 Diabetes, and Crohn’s

Yeah, this is like the holy grail of transplantation research

Honestly I am so excited about this, it could litteraly be a way to eliminate deadly allergies, like foods and insects of course, but also medication and seasonal allergies

Yeah, if this works as advertised, I have friends and family whose lives will be immensely better. And imagine being able to prevent the progression of diseases before they cause permanent damage in younger patients - there's tremendous potential for better, healthier lives.

If it works, this is huge. Could potentially also treat post-viral conditions such as chronic fatigue or even Alzheimer's.

Per my wife (an actual microbiologist with her undergrad focusing on immunology - providing this as context for why she I asked her, not just an appeal to authority) the core mechanisms are not new, quoting verbatim from messages:

    That’s actually not new science 

    That’s antibody / mhc molecule immuno treatment 

    In cell lines and just started in mice 

So this sounds like what they've done is found a set of molecules/receptors/something that are responsible for the MS and chrohns auto immune disorders that don't take out other things.

This doesn't mean this isn't a major development - MS especially is an awful condition - just the underlying mechanism isn't itself new.

The referenced study https://www.nature.com/articles/s41551-023-01086-2 says "a mouse model" and "non-human primates":

"We show that pGal–antigen therapy induces antigen-specific tolerance in a mouse model...as well as the suppression of antigen-specific responses to vaccination against a DNA-based simian immunodeficiency virus in non-human primates"

The article also mentions that phase I trials have been carried out with humans:

"initial phase I safety trials have already been carried out in people with celiac disease...and phase I safety trials are underway in multiple sclerosis"

In at least some cases type 1 diabetes is considered an autoimmune disease as are the other diseases listed in the headline. They're using the "vaccine" to turn off the body's overreaction to a specific antigene. This is huge if this makes it through human trials. There are a lot of people suffering from various autoimmune diseases.

From the article:

"A typical vaccine teaches the human immune system to recognize a virus or bacteria as an enemy that should be attacked. The new “inverse vaccine” does just the opposite: it removes the immune system’s memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, rheumatoid arthritis, or Crohn’s disease, in which the immune system attacks a person’s healthy tissues."

The rest of the article goes into some details of how it works.

It's usually (70% of the time, or more) caused by the host immune system destroying the beta cells in the pancreas.