Not depression, but I had pretty significant (to me) anxiety that seemed to permeate every spare second of my waking life. I saw a TikTok recently of someone who said Magnesium supplements helped them very quickly. I thought “what the hell” and tried it. I was shocked how fast it worked for me. Within two days the anxiety melted away.
Placebo, maybe. Couldn’t care less. It worked, for all my purposes.