The biggest issue I’ve had is that some of these less popular libraries (both by Microsoft and not) have some truly tasteless APIs, I think mostly stemming from older versions of C#, and for some reason the lowest quality stack overflow answers are much lower for C# than in python — there appears to be much more cruft and outdated information in blogs, stack overflow in C#-land than python. Really in general I feel like python/rust has a higher floor for taste than C#, but at ceiling it’s competitive.
I’m pretty sure though that startup language choice has nothing to do with practical considerations — it’s largely a popularity contest based on hype cycles, and C# is well past its hype-prime.