'This was to prevent anyone with the gene from being hunted by prescient hunter-seekers.'
https://dune.fandom.com/wiki/Golden_Path#Objectives
The evolution of prescient hunter-seeker. You can look it up in 'God-Emperor of Dune' yourself if you want. It's one of the main plot points. The evolution of autonomous, self replicating killer machines driven by human power dynamics.
What else is AI but the attempt to predict and exploit human behavior?