The vaccines turned an extremely dangerous pandemic into a tolerable-if-still-worrisome endemic disease. This lancet paper represents a pretty good consensus belief that vaccines saved 14M lives. Our "willingness to accept a lost cause" was informed heavily by the justfied belief that it wouldn't kill us.
https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
Basically, yeah. "All that stuff worked".