I can confirm that even a 1-by-1 Lego brick can withstand the full weight of an adult human male at 2 in the morning.
...my foot on the other-hand...
...my foot on the other-hand...
We can also observe this (to a lesser degree) when they build two story Lego statues like at the Mall of America.
I'll admit I've never seen a huge Duplo statue, but I assume the load limits are similar.
https://stepinmath.wordpress.com/2016/08/27/logic-with-the-c...
Thus an adult human male (who sleeps, say, 10pm to 6am) is less likely to break a lego brick at 2am than at midnight and more likely than at 4am.