Antioxidants found to spur cancer growth and metastasis in mice
news.ki.se
news.ki.se
I say chlorides because consistently for many studies, notably zinc but applies to Iron, phytates and tannins bind and inhibit the absorption of these two metals, but leave copper alone. Chloride based metals get into the body very quickly.
I'd also look at the mistakes in some studies, different parts of the world have different theories and its possible if you look at enough to see old theories being quoted and not assertions from more recent studies.
The jury is out on what is a good diet to consume for different types of cancer let along a healthy life, its contradictory at best, zinc is good for tackling some cancers, and bad for others. Copper is good for tackling some cancers and not others, and that just looking at two common metals in the diet.
So if the experts knew, I think they would recommend a diet to go on, but they are so steeped in patient privacy they undermine their own authority I think, not to mention come across in general as quite dictatorial.
I have also been messing with some body building amino acids and I liked histdine which is one of the four amino acids that start with zinc, the other three are glutamic acid (glutamate), aspartic acid and cysteine (N-Acetyl Cysteine). Histidine is precursor for histamine which helps immune cells migrate through tissue. Aspartic acid mediates some cysteine based immune responses.
Its also worth looking at vit D, a Wellcome trust study had reverse engineered the human genome about a decade ago and found that most of the Vit D receptors are concentrated around immune system genes (2776 iirc). But you need zinc and cysteine to build the zinc fingers found on these vit D receptors and vit D will switch on some genes and switch off some genes.
Oncologists have access to the testing and measuring equipment, I see no harm if interested in this stuff to get the data from their tests and check their theories against studies found in google scholar, if you wanted piece of mind.
These experts dont always publish their theories so there isnt the transparency, and they dont ask about diet which can be significant in some cases, so they undermine their expertise imo.
And thats before you get into the debate of hackers tampering with results and other things which seem to question the fragile nature of computer security.
And I'm not recommending anything other than question the experts.
Again, recommendations from a health guru book and not an actual doctor, that I'm just copying here in case it helps. I have no experience with cancer other than a close relative passing away when I was much younger.
Encouraging them to stop eating seems like it would just accelerate death.
Did it make a difference in effectiveness? I actually have my follow up scans tomorrow to find out. As you can imagine, I really really hope so.
There are studies on fasting with chemo.. and depending on the type of cancer its either effective or ineffective. My comment was specifically about the end stages where cachexia is common (from my link above):
"Cachexia is associated particularly with cancer where the prevalence can reach 50–80% in advanced malignant cancer."
And all of the advice Ive found says fasting is not recommended for patients with cachexia.
It sounds like it was fine in your case though because you were able to regain the weight. Best of luck with your scans.
In the context of chemotherapy, couldn't that be a quantitatively useful benefit?
"Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism"
I did upvote you.
I don't know how true is what they claim in the book, but basically it's the following.
All cancer cells obtain their energy from fermentation and not oxidation. They use glucose for that fermentation process and they propose fasting and a ketogenic diet as a treatment.
Antioxidants can actually promote fermentation and inhibition oxidation.
All that being said, she pretty much abandoned all of the additional about halfway through her treatments. She had to have half her liver resected, and she had a HIPEC procedure at the same time. When they did the final biopsies on her metastases in her liver, it was 100% dead. She's now been NED (no evidence of disease) for a few years now. I don't have delusions that it will never come back, but I can hope.
I don't know if anything she did helped the chemo do it's job. It's not exactly something you can A/B test. I think it's possible, but I also think her being so young and in good shape to start with made the biggest difference.
My doctor literally gave me such an oral prescription as my vitamin D levels are low.
You don’t need a lot of Vitamin D to avoid deficiency. Taking even 5000 IU for an extended period of time can cause Vitamin D excess.
Vitamin D confuses a lot of people because it accumulates over a very long time period. You can take the same dose every day but not approach overdose range for a year or more. It builds up if you’re taking too much, and there is a lot of overlap between “too much” and some of the regimens pushed by health influencers.
To be fair, if that's the effect you're going for it doesn't seem like the best option. If you want something to promote oxidative stress, take something like pawpaw supplements or a drug like metformin.
Tumors need more energy than normal cells, and oxidative stress interferes with the ability of your mitochondria to produce energy. So yeah, it makes intuitive sense that antioxidants are not what you'd want for cancer. Although as you mentioned, these systems are pretty complicated and there are a lot of chemicals that can act as antioxidants in some circumstances and oxidative agents in others.
Isn't the mitochondria usually silenced in cancerous cells?
Could this be why meditation was shown to reduce tumor size? I saw a recent article, on here I think, about a study showing proof via imaging that meditative practices of aligning chakras was successful at reducing tumors where chemotherapy could not. Could it just be that extreme relaxation causes the tumors energy demands to exceed the bodies supply in a relaxed state?
Cancer sucks and is complex enough without adding more variables. Especially if you’re dealing with immunotherapies and managing secondary infections and other complications. Plus, any problems that develop are going to be divvied up between various specialists.
High-dose vitamin C enhances cancer immunotherapy https://www.science.org/doi/10.1126/scitranslmed.aay8707
posted this in response to the wrong comment earlier
They've been reporting this since 2015:
https://newatlas.com/medical/antioxidants-stimulate-blood-ve...
The actual press release from Karolinska might be more informative and a better link than whatever New Atlas is:
https://news.ki.se/antioxidants-stimulate-blood-flow-in-tumo...
URL changed as well. Submitted URL was https://newatlas.com/medical/antioxidants-stimulate-blood-ve... (the same one you mentioned there, so I couldn't track the 2015 ref)
Most animals make vitamin C internally in the amounts they need. We are only one of a handful that do not, because we have a mutation that prevents us from finishing the process, otherwise we would also be making it ourselves too.
Animals don't drop dead left and right from cancer. I would suggest if one tries to eat a balanced diet then this will help with avoiding cancer.
Lastly, the longer you live, the more certain it becomes that you will get cancer of any type. What we are doing here is trying to live healthy enough that we die before we live long enough for cancer to become a problem.
Inuits consuming their diet of purely meat and fat for 6+ months a year do not get scurvy, and it is not a generic mutation either, as testified by Europeans that lived among them and adopted their diet without issue. See Vilhjalmur Stefansson, the ethnologist who spent years living and eating like an Inuit, and anyone following a strict carnivore diet.
The entire meme about sailors getting scurvy because they didn't eat their vegs is because their diet was pretty much poor quality carb-heavy food like rice, potatoes and bread, so even just supplementing with lemons was enough to keep scurvy at bay.
Though not as much as humans. The diet factor is a huge part for sure. Virtually all the major bodies like the UN agree on this.
Similarly, other species of animals cannot synthesize certain nutrients they get from their diet. Cats, for example, cannot synthesize taurine and must get their required taurine from consuming meat.
This is speculative and honestly not the simplest explanation. Deleterious mutations will happen in the absence of selective pressure, and there was no selective pressure.
You don't have to cast everything as evolution playing 4D chess. Sometimes genes just break, and not for good reasons.
You’re describing absorption tolerance, but the body doesn’t need anywhere near that much Vitamin C.
The idea that you need to “titrate to bowel tolerance” as the alternative medicine practitioners say is rather nonsensical. Nothing in the diets we evolved to consume has anywhere near enough Vitamin C to cause loose stools (from Vitamin C excess)
You can consume more than enough Vitamin C for your body to ever use with regular food. Taking these megadose supplements at unnaturally high doses may get some absorbed into your body, but it just gets excreted back out.
Absorption and use are two different things.
Intravenous High-Dose Vitamin C in Cancer Therapy https://www.cancer.gov/research/key-initiatives/ras/ras-cent...
High-dose vitamin C enhances cancer immunotherapy https://www.science.org/doi/10.1126/scitranslmed.aay8707
Look at what the title of the research article is: "Antioxidants stimulate BACH1-dependent tumor angiogenesis"
The researchers conclusion: "We conclude that BACH1 is an oxygen- and redox-sensitive angiogenesis transcription factor."
Then compare how the author of the article put it.
Taking dietary supplements full of antioxidants could help cancerous tumors grow - https://news.ycombinator.com/item?id=37349870 - Sept 2023 (66 comments)
Emphasis mine.
It seems from studies I’ve read that it causes big problems either having too little or too much antioxidants. I haven’t had time to read this one yet but observational studies seem to pretty overwhelmingly show positive health benefits for a diet that has a relatively high amount of antioxidants, but RCTs giving very large does of antioxidants often have to be terminated early due to adverse effects.
So seems like it’s hard to hit the ‘too much’ level with diet but very easy with supplements.
But as you say, there should be a threshold you don't want to cross with antioxidants, and supplements can easily do that.
But also note that vitamins aren't FDA regulated, and they're a complete grab bag in terms of quality and bioavailability.
Generally unless prescribed by a doctor for a specific condition or if you know your diet is lacking in a specific vitamin (like B complex for vegans), you get more than enough from your diet. [1]
[1] https://www.health.harvard.edu/mens-health/do-multivitamins-...
I'm wanting to figure out the best way to regulate the things in my body with less Kidney stones, uric acid etc, and that won't upset my depression, anxiety, and ADHD.
I think sure take vitamin D but don't expect much.
[1] Friend that's a public health nurse says they're seeing kids with rickets and bad teeth in Marin County. Because vegetarianism, sunscreen and milk alternatives. They don't see any of that with poor kids in Oakland because they're on WIC and not getting woo woo healthcare.
What a time to be alive.
Seems to me that few people eat a perfect diet, and I’d be amazed if there’s evidence dieticians work better than multivitamins. People don’t eat right, not because they need education, but because unhealthy diets are tasty, cheap, convenient, etc…
And multivitamins are not all the same, they have radically different formulations, so I doubt the results of any research that didn’t specify a specific multivitamin, or break results by gender or age. (Vitamin needs/ deficiencies are often age related. Consider subsets like prenatal vitamins, vitamins for the elderly, etc…)
I think we're talking about different things here. You're talking about the risk of toxicity from taking high doses of fat-soluble vitamins. I'm talking about the risk of taking anti-inflammatory supplements / drugs generally (regardless of dose).
In general I agree with you on taking vitamins, however the reason I take a very low dose of Vit E is because I have a genetic predisposition to liver inflammation. Vit E is one of the few things which helps me reduce this inflammation which helps me mitigate against long-term damage, but reducing inflammation too much can increase risk of liver cancer, hence why I only take a low dose. This is also the reason patients with late-stage liver disease are typically not given Vit E because they're at a higher risk of developing liver cancer.
On taking Vitamins generally I think most people in the West would benefit from a high-quality low dose Vit D supplement. Something around 1,000 - 3,000 UIs daily is almost certainly safe and the majority of people would benefit. Higher doses are probably preferable in many cases, but you should be monitoring blood concentrations at that point to ensure you're not reaching toxic levels. Otherwise, yes, supplementing is silly unless you have a reason for it.
I hang out in a lot of liver health communities one of the most common reasons I find people have unexplained elevated liver enzymes is because they're taking low quality (often herbal) supplements.
So long as your serum 25OHD concentration is >50nmol/L according to this meta analysis, there's no clear effects. [1]
> In conclusion, supplementation of vitamin D-replete individuals does not generate overall health benefits; however, correction of severe vitamin D deficiency remains essential.
Probably would be a lot better off going outside and synthesizing your own. Spending time in nature and in the sun does a lot of other useful things - for instance UV exposure induces nitric oxide synthesis too, which lowers blood pressure. [2]
> So long as your serum 25OHD concentration is >50nmol/L according to this meta analysis, there's no clear effects.
I mostly agree. Above 50nmol/L it's not so important, but most evidence would still point towards it being slightly healthier to be on the higher end of the reference range for Vit D, so therefore if you wanted to optimise your health you probably should be targeting around ~150nmol/L. We know our ancestors would have had Vit D concentrations around these levels so there's no good reason to think it would be unhealthy either.
Additionally, and what you missed here is that a lot of people in the northern hemisphere get close or fall below that 50nmol/L clinically deficient level during winter months. This is why I think in general it's probably better for people to take a low dose of Vit D than not (especially during the winter).
But to your point, if you're spending time outside and getting a bit of sun exposure every day then it's probably not needed.
Yeah, I certainly don't think it's unhealthy, I just haven't seen any studies demonstrate really any effect at all over the lowest normal value. If you have some studies I'd love to see them so I can cite them in the future.
I think we're basically in agreement.
Anyway, the conclusion was that more antioxidants is not necessarily better and that we still don't understand how things work.
Vitamin E as α-tocopherol has been associated with increased prostate cancer[3]. Natural tocopherols rich in γ-T, γ-TmT, or similar tocopherol mixtures show more promise for cancer applications[4].
1. https://www.cancer.gov/about-cancer/treatment/cam/hp/coenzym...
2. https://youtu.be/9Z7X9WPWv4Y?si=avOV0u4ruy_zNslr&t=746
> The researchers say their findings highlight the potential risk of taking antioxidant supplements when they’re not needed.