There is a weird contrarianism a lot of people seem to relish in when it comes to natural medicine having an effect.
The reason pharmaceuticals have studies that prove effects is because there is a giant profit engine powering them and a regulatory system requiring it. It's hard and expensive to do a huge well controlled study of garlic because most modern people eat garlic as a regular part of their diet. It would be hard to find statistically significant effects for prozac if the control group used it as a seasoning.