Deep into the ad topics I managed to find a place where I could search for topics and indicate that I would not like to be targeted for those, and that seemed to have done something. But it replaced one topic with another.
It's crazy how they managed to ruin their own product. They're rapidly bleeding real users and it's totally their own fault. Facebook used to thrive with close social interaction mixed with some suggested content that seemed to be actually relevant. Now it's just anonymous filler content and they don't even show relevant posts anymore.
The only reason I'm still on Facebook is because our local town's official communication is through Facebook (sad, I know) and the neighborhood is active there as well. Otherwise I would have happily deleted my account a long time ago.