It doesn't really apply in things such as what happens after death, because such a thing is essentially by definition immeasurable and unfalsifiable. So any view largely becomes an opinion. There is no factual basis for anything.

For myself, I think what little evidence we have to form an opinion would based around the absurdity of existence itself. If you really think about the fact that we actually and undoubtedly exist it's really quite terrifying. The argument that the initial big bang could have been driven by quantum fluctuations is meaningless as you always end up with the question of what created the laws enabling such fluctuations, the 'void' in which it happens, or or even quantum mechanics itself. Of course if one takes a deistic point of view you end up with the exact same issue. If God created everything, then what created God?

It's years of pondering this that led from atheism to agnosticism. Even intellectually appealing "answers" like the simulation hypothesis offer no real answer. Imagine you 'die', 'wake up', and pat yourself on the back upon finding out it was indeed a simulation. Well you still have no answer whatsoever because the question of creation now emerges once again in your new reality. Turtles all the way down, simulations all the way up?