If you are going to mess with complex systems, such as feed yourself aspartame, vape, give pregnant women a synthetic sedative and medication for morning sickness etc., you do it for a high potential gain that offsets potentially huge downsides. Benefits of aspartame are close to nil; if anything it probably makes things worse because people think they can consume more ultra processed foods sweetened with it because such foods have "fewer calories".
Time is not evidence of safety, that is an odd claim (see smoking tobacco), thankfully we have the scientific method to investigate hypotheses like "x is bad for you".
We might still get lucky and get beneficial side effects of aspartame or peach-flavored strawberries that makes us faster, stronger, smarter, but with these things the luck usually works in the other direction.