Obviously it greatly depends on what you're doing. If you're using a relational database as a glorified key-value store for offline or batch processing of a few hundred megabytes of data, sure. Hell, just serialize and unserialize a JSON document on every run if it's small and infrequent enough ¯\_(ツ)_/¯

If you've got a successful data hungry web service with a reasonably normalized schema and moderately complex access patterns though, you're not going to be looping over the whole thing on every page load.