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Comment by FirmwareBurner | Hacker News Reader

>I never understood how some people can have a coffee in the evening and go to bed just fine

By building tolerance and genetics.

Regarding genetics, are there enzymes that some people lack, and that they can take to digest caffeine better?

This one https://en.m.wikipedia.org/wiki/CYP1A2. I've read somewhere that eating Broccoli enhances its activity, but likely too much is needed to have noticable effects from what I recall.

If only there was a short-acting stimulant and antidote available as a combo..

Of course, that’s called a speed ball. An upper and downer. Also poppers and screamers and small world.

“We buy drugs” whitest kids u know : https://m.youtube.com/watch?v=I2AQ6FwpSrc

Anyways, in all seriousness the idea of taking something and then taking something else later to counteract the effects, not good but popular in black, gray, and white market.

I think this weekend I’ll give up caffeine, I’m a slow metabolizer.

I was thinking more in terms of actual antidote by either binding the active substance or speeding up its metabolism, rather than having two substances acting in opposing directions.

Anyway, I gave up caffeine earlier this year and am quite happy with the results. Steady and calm energy, no frantic meandering of thoughts, no clinging to details anymore. Once every few weeks I'm craving the euphoric buzz and drink half an Espresso, but typically regret it later the same day as I'm unable to sleep and, interestingly, tend to wake up in the middle of the night for a couple of days after.

> If only there was a short-acting stimulant and antidote available as a combo..

I know that energy drinks use taurine to combat some of the effects of caffeine, but I don't think it will work for sleep.

And age. I used to do this fine in my 20s. 30s not so much.

Or by having ADHD - coffee before bed can give me just enough focus to fall asleep.

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