For example, he could have talked about the N-Hexane poisoning without lying. He could have cited news reports, or traveled to interview people, or done it over the phone, or even gotten the info from secondhand interviews. He could have said "imagine a man who..." and proceeded to paint a painful picture based on the facts that were already public.
But he didn't. He chose to pretend he had met these people. He would say that made the story more emotionally impactful, and maybe that's true. But it also poisoned it. It was a very condescending move to pull on his audiences; there is neither artistic nor factual integrity in it.
If he had stuck to the facts, he would still have had a great performance. Too bad.