Noatime, disable swap, logs in RAM, /tmp in RAM, .xsession errors in RAM(With logrotate or it will fill up! So many random problems can make a problem there), chromium profile folder in RAM if you do kiosk work(Browser makers must hate flash!).
From what I hear Home Assistant is still not the easiest if you want to run for years on a card, not sure if that's fixed now, but it's one of the big factors blocking me from moving to HA.