Irrationality and gullibility are underrated.
The fear many have about attempting such things mirrors the fear of e.g. psychedelic experiences -- the fear of "never coming back". Ironically, only living through this fear is what causes the bad trip in the first place. Egos, man, egos suck.
Where is the evidence for this? None.
> the fear of "never coming back"
Psychedelics sound like fun, but I have seen quite a few broken people on the streets, all because of them. It's not just fear, it is a serious concern.
Broken people on the streets are most often people with prior serious mental issues who were pushed over an edge. Typically by intense trauma (living on the street really fucking sucks for lots of reasons) but also to a lesser extent this can be drug-induced. However the drug class that usually performs this role is amphetamines ("meth psychosis"), not tryptamines or phenathylamines.
But you're clearly not willing to listen, so what use is there actually engaging here?