Firefox—my daily driver—still supports the "main" uBlock Origin (and I'm a somewhat heavy user of features unavailable in Lite like custom filters), but I had been waiting for Lite to be available and immediately went ahead and replaced uBlock Origin with uBlock Origin Lite.
The security win can't be understated: with its permission-less design (enabled by MV3) I am down to zero third-party developers that can get compromised and silently push an update that compromises all my web sessions. Sure, attackers could still get into Mozilla, Apple (as I run macOS), or cause a backdoored update to be pushed via Homebrew (how I install unsandboxed applications when no web app is available, which thanks to the likes of WebUSB is getting less common), but unsandboxed browser extensions were clearly the lowest hanging fruit, so this update (and MV3) significantly raised my security posture (and transitively that of projects I have access to, and that of their users).