RAID 1, you mean? Because that way you still have a complete copy of your data if one drive fails.
BTRFS is excellent for the use case of a wide variety of mismatched drives, because it supports adding and removing drives and rebalancing the array. But for the moment only the RAID 1 modes are really trustworthy. I have a NAS consisting of drives whose advertised capacities in GB are: 1000, 1000, 1920, 2000, 2048, 2050, 3840, 3840, 4000. But it started as a pile of infamously unreliable 3TB hard drives.