High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma in Mice | Hacker News Reader

High-Dosage NMN Promotes Ferroptosis to Suppress Lung Adenocarcinoma in Mice

ncbi.nlm.nih.gov

31 pointsbirriel9 comments

They looked into the effect of NMN (Nicotinamide Mononucleotide) on lung adenocarcinoma (a type of lung cancer) cells.

It may be that high levels of NMN inhibited lung cancer growth by causing cancer cell death via ferroptosis, acting through a pathway involving NAM, SIRT1, AMPK and ACC.

Yeah this kind if work is usually meh. It’s unclear if the high concentration is physically relevant in humans, plus it’s not clear if it causes any other problems, and plus it’s not clear how it compares to existing treatments. So maybe promising but v v early

You cannot completely reject it, this is the first step, the next is human clinical trials.

Obligatory XKCD: https://xkcd.com/1217/

Here are some interesting videos on NMN: https://www.youtube.com/@DrBradStanfield/search?query=nmn

I think the pragmatic position is that NR has better testing in humans and is a bit cheaper, and there's no reason to think that plain Niacin isn't just as good at this point if you can deal with the flush - we don't really have enough solid testing yet, and it's extremely cheap.

I'm interested in niacin, especially for it's effects on lowering LPa, which it seems to be one of the few ways to do so. However, I thought the common concern is that it promotes insulin resistance. Even though it seems to be a bit of a miracle drug for cholesterol numbers, on paper, it's effects on actual longevity are non-existent, proposed to be due to the IR. Have you read otherwise?

> common concern is that it promotes insulin resistance.

Chromium can offset insulin resistance, and whilst niacin can increase growth hormone and those ensuing reactions in the body, the demand for chromium will go up.

Chromium also increases Interleukin 1 and 2, which is like the the homing beacon for the immune response. Ferroptosis seems to me like using Fe based ROS to do the destruction, when not enough beta alanine and thus Super Oxide Dismutase to neutralise the feROS is present.

Not enough chromium, you'll see obesity, diabetes, impaired immune response.

Ironically smokers are probably after the "toxic" heavy metals like nickel which causes mitochondria dysregulation in much the same way mercury in amalgam dental fillings cause mitochondria dysregulation to reduce bacteria. Problem is smoking is bypassing the evolved normal digestive system measures to handle these heavy metals, like bile acids.

I think we dont get enough nickel in out diet considering it also seems to reduce the incidence of osteoarthritis, and a zinc-nickel combo is fantastic for bones. Zinc will give you a better cholesterol profile as well, and has been show to shrink receptors on some bacteria, which effectively starves them reducing the uptake of manganese, which could explain why zinc is considered antibacterial.

Problem with nickel inhalation from smoking or welding is it causes lung cancer as its a metallic allergen, and everything in moderation, which is harder to control via inhalation when compared to digestion.

Is niacinamide the same effectiveness as niacin?

It's chemically one step closer to NR and NMN -- it's already the amide, just add the R and MN.

But it's also as useless at longevity in animal studies as plain niacin. Technically that's the same "effectiveness". Feeding in more raw material won't do so much when conversion to the active form is tightly regulated.

(Niacin lowers cholesterol via HCA2, something nicotinamide, NMN, and NR does not hit.)

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