(Cold) Lattice Confinement Fusion
www1.grc.nasa.gov
www1.grc.nasa.gov
Not in the sense of nanomachines, but using modern materials science: deliberate and reproducible crystalline construction, informed by large scale QM modelling of EM material properties.
AlphaFold consumes, and improves on, raw electron density functionals (EDF) for protein folding. Perhaps there is scope for similar improvements over existing methods for modelling and exploring the space of metallic or complex salt crystals.
Even just 2x or 4x higher energy density batteries would have a tremendous impact on electric aviation and drones, phones, and so many more things.
Sw with super conductors except that would be even more exciting, and we would get a new generation of incredibly sensitive sensors and antennas.
I could go on and on but the main point is like what you said, the materials drive the breakthroughs in innovation if technology (in many cases)