What do you mean by this claim that what is io bound today may be cpu bound tomorrow?
The other way is that sometimes a little more load perturbs the system so things take a lot longer. I've had systems that work fine until you hit X% cpu, then it jumps to 90%+, because of say lock contention; sometimes N is 80% so whatevs, but sometimes it's 25%, and then you need to find and fix the bottleneck.