it's not very realistic
It is totally realistic. I have multiple projects running that do not use any external code. With millions of users.Those projects are PHP though. PHP has a lot of bells and whistles on board. Unfortunately with PHP 8, they started introducing a lot of breaking changes. So they lost my trust and I will use Python for new projects.
Not sure yet if I will use Django (As you said, it seems pretty stable) or do the good old CGI approach. If I do the latter, I will probably write a new CGI library for it, because in the Python ecosystem it is all about long running processes nowadays and I think that is the wrong approach.