"the life cycle of mice are fundamentally different than humans. Their life span is too short to be a comparable organism when aging is the topic of research."

You know, I feel ambivalent about this. On one side, you are obviously right, mice are very different from people.

On the other side, the similarities between a 2 y.o. mouse and a 80 y.o. human are striking. Grey hair, weakening muscles, cataracts, declining memory, worse organ functions across the board, hunched back, tremors, compromised immunity etc.

It certainly looks like fundamentally the same process, only sped up 40 times.