I'm esp. interested in any interaction with food. Because I get depression 4 days after I ate a food. I don't have any other symptoms than low energy and a sense of impending doom. Symptoms stay for 3 days then go away. Started collecting the info in my github. I'm very interested if anyone has more ideas.
- Gastroparesis
- Thiol intolerance (impaired sulfur metabolism) - could try molybdenum and maybe Boron supplementation (ask doctor if ok)
- High gut permeability („leaky gut“) -> undigested proteins enter blood stream -> autoimmunity (eg via viral mimicry; all kinds of viruses can do that, but COVID and EBV come to mind). Water fasting could help, maybe digestive enzymes
- Mechnical interaction, eg dysbiosis -> bloating -> cervical spine misalignment -> more bloating due to vagal nerve pinching (try massaging back of the neck vigorously to see if depression disappears for a while)
- Auto-brewery syndrome
All of those can be downstream issues of systemic issues, like hypothyroidism (which has been shown to be caused by microbiome metabolites; I wouldn’t just down the next best yogurt though, but look at studies around Bifidobacterium Longum, which looks promising; probably others too).
Although there is less research into it than l-glutamine, there is rapidly growing interest into the effects of creatine supplementation on dysfunctions of the epithelial barrier (which would include intestinal permeability aka "leaky gut") [1]. The upshot is that it is an well studied supplement that is very well tolerated by almost everyone.
Zinc carnosine is another one that can be helpful, if tolerated. However it is believed that enteric-coated formulations are required to be effective (which may be hard to find) due to very high absorption rates and susceptibility to stomach acid prior to reaching the intestines [2].
[0] https://www.mayoclinic.org/drugs-supplements/glutamine-oral-...
[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8145094/
[2] https://www.sciencedirect.com/science/article/pii/S221074012...
I seem to be okay with fermented thyme.
Pepper is no good, swollen eyes, but chilly seems to be okay. Those are never consumed in big quantities, I could test with chilly capsules though and maybe I will.
Diet consists of Lamb, once a day, then some yoghurt or kefir in the evening. Some koffee and milk as well.
Haven't collected everything yet, maybe you find something that helps - or can add some. Trying to get diagnosis for leaky gut, it's a drag to get an appointment. https://github.com/cutestuff/FoodDepressionConundrum
HOWEVER, I am constantly experimenting with foods, isolation, etc. - and I discovered that PLANT-BASED milks or creamers for my coffee give me TERRIBLE CFS. - Almond Milk - Cashew Milk
Specifically "big brand" names you find at chain stores. They must be chemically treating these foods with something. I don't trust them.
Back to cow's milk for me.
So it's a stress response, not necessarily causal. It's long been suspected that some sort of perennial stress state was involved in this problem (anything from adrenal fatigue to illness genes never turning off). So does this tell us more or is this just another biomarker?
Though I say 'just', finding a biomarker for CFS would still be something people could be tested for, which is way better than where we are now.
This is what some biologics do.
I have spoke to people who had improvement after doing an antihistamine protocol. In the long covid/cfs space.