According to something mentioned in passing in a Scott Manley (amateur space youtuber) video about deep-sea diving: at high enough pressures you'll get similar effects from helium. It's thought that you can avoid this by subbing out the helium for hydrogen, but nobody so far has been insane enough to try.
I assume liquid breading is much easier at that point.
>The interesting thing about this research is that it sort of makes sense, and yet is very surprising. We’re basically continuously narked, we’re just so used to it we don’t even know.
I'd be interested in knowing how people are mentally when they're in spacewalk/Mir conditions. (1/3rd atmosphere, pure oxygen.)