I wonder if there's a cheaper filler gas we could use besides He. Perhaps methane, hydrogen, or acetylene, though they're quite flammable.
EDIT: Although it seems the Apollo 1 fire happened with a pressurized oxygen atmosphere, not reduced pressure. Still, reduced pressure has its own dangers, because there could be sudden re-compression if the vacuum chamber failed. Re-compression barotrauma appears to be poorly studied (people don't usually work in partial vacuum). Or you could get crushed to death by the vacuum chamber imploding.
Working from inside a hard-shelled pressure vessel would definitely be inconvenient. You could also build your home office 5000 m above sea level. Or work in a high-altitude balloon.
Either way, the rebreather option seems a lot more practical.