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That list seems pretty incomplete/sparse. It's pretty unsettling that paracetamol, as common as it is in modern medicine, would still lack a known mechanism of action. I wonder if it's just a hard question to answer, or something more boring like research cost vs benefit ratios etc.

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It is an extremely hard question to answer. Think about how hard it is to debug software, even though software is designed by humans, is intended to be readable by humans, and has tools to help us in analyzing it. Then think about how much harder it would be to understand a system that instead came about by billions of years of chance mutations building up to develop self reproducing systems that are not at all meant to be easily understood, and that follow much more complex rules (quantum mechanics) than binary computers do.

there’s a relevant xkcd, as usual: https://xkcd.com/2682/

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