My uncle had ALS and was slowly losing his ability to speak. I visited and in order to hear him, we had to gather around him closely. It was very fatiguing for him to project his voice.

I went to a few audio stores and jerryrigged a portable mic-speaker setup that could attach to his wheelchair. No software, just the right series of devices and adapters. It worked well and provided a huge relief for him and our family. Nothing impressive technically, but definitely the physical thing I'm most proud of making.

His blog, for any curious about his ALS journey: http://cheeseaisle.blogspot.com/