More mainstream audiences can't get things done for them without e.g. a cross-subsidy from Nintendo who can afford to treat the anime as a loss leader for the video game or collectible tie-in.
This is a shame for folks who care about distributional access, by the way. For example, there exist people who think that shoujo manga is a Good Thing (TM) for the U.S. comic books industry because it provides young girls with stories they can relate to and helps counteract the insanely rampant hypersexualization and misogyny of the US comic industry. Unfortunately, shoujo manga has fairly few crossover hits and hasn't had a commercialization success in the US comparable to e.g. Disney's line of princess products, which means that the industry is largely a) not willing to devote marketing muscle to promoting it as much as Bleach / Naruto / Pokemon / etc and b) some would argue that the old guard justify their marginalization of the genre and its fans by saying that (because of their marginalization!) it failed to sell well.
n.b. I'm neither a fan of shoujo manga nor a great lover of women's studies but someone who was both had veto power on my degree, so you can bet I at least listened for the more credible claims.