I put PyPy in production at a previous job, running a pretty high traffic Flask web app. It was quick and pretty straightforward to integrate, and sped up our request timings significantly. Wound up saving us money because server load went down to process the same volume of requests, so we were able to spin down some instances.
Haven’t used it in a bit mostly because I’ve been working on projects that haven’t had the same bottleneck, or that rely on incompatible extensions.
Thank you for your work on the project!