I wanted to write a codegen tool that would auto-generate bindings for C++ code, and it turns out that "libTooling" is the only reasonable way to get access to the proper info you need from C++.
Another alternative is "libClangSharp", from Tanner Gooding who works on C# at Microsoft.
python aside, having gone down this rabbithole, and still not infrequently revisiting said rabbithole, I don't believe using *clang like this is a winning strategy. Because of the number of corner cases there are in eg C++17, you will end reimplementing effectively all of the "middle-end" (the parts that lower to llvm) for your target language. At that point you're not building bindings anymore but a whole-ass transpiler. Binder fails to be complete in this way.
My current theory is to try "synthesize" bindings from the llvm ir (a much smaller representational surface). Problems abound here too (ABI).
Alternatively there is https://cppyy.readthedocs.io/en/latest/, which I don't completely understand yet.